反应 #935826

反应方程式

4-Chloro-3,5-dinitro-o-xylene

i-propylamine

→

orange solid

收率 80.0%

N-Isopropyl-3,4-Dimethyl-2,6-Dinitroaniline

收率 80.0%

反应条件

后处理

1. 1
   温度refluxed for 12 hours
2. 2
   温度The mixture is then cooled
3. 3
   workup.ADDITIONpoured into 100 ml
4. 4
   萃取of 5% hydrochloric acid and extracted with diethyl ether
5. 5
   萃取The ether extract
6. 6
   干燥is dried over magnesium sulfate
7. 7
   其他Removal of the drying agent and solvent
8. 8
   其他leaves an orange oil which
9. 9
   其他The product is recrystallized from methanol

实验过程

4-Chloro-3,5-dinitro-o-xylene (10.0 grams, 0.043 mole) and i-propylamine (10.1 grams, 0.17 mole) are mixed and refluxed for 12 hours using an efficient reflux condenser. The mixture is then cooled and poured into 100 ml. of 5% hydrochloric acid and extracted with diethyl ether. The ether extract is dried over magnesium sulfate. Removal of the drying agent and solvent leaves an orange oil which readily solidifies. The product is recrystallized from methanol to give 8.7 grams (80%) of an orange solid with melting point 69° C. to 70° C.

来源