反应 #93538

反应方程式

pyridine

α-mercaptomethyl-β-phenyl-γ-butyrolactone

p-n-butylbenzoyl chloride

→

title compound

收率 79.1%

α-(p-n-butylbenzoylthiomethyl)-β-phenyl-γ-butyrolactone

收率 79.1%

溶剂

ethyl ether

ethyl ether

反应条件

后处理

1. 1
   其他After completion of the reaction
2. 2
   洗涤washed with 10% hydrochloric acid, 10% aqueous sodium hydrogen carbonate
3. 3
   干燥dried over magnesium sulfate
4. 4
   workup.DISTILLATIONthe solvent was distilled off
5. 5
   其他The crude product thus obtained
6. 6
   其他was purified by a silica gel column chromatography

实验过程

To a solution of 1.5 g of α-mercaptomethyl-β-phenyl-γ-butyrolactone in 30 ml of ethyl ether were added at room temperature 4.3 g of p-n-butylbenzoyl chloride and then 1.9 ml of pyridine. The mixture was kept at room temperature for 2.5 hours. After completion of the reaction, the reaction mixture was diluted with 100 ml of ethyl ether, washed with 10% hydrochloric acid, 10% aqueous sodium hydrogen carbonate and then satureated saline, dried over magnesium sulfate and the solvent was distilled off. The crude product thus obtained was purified by a silica gel column chromatography to give 2.1 g (yield 79%) of the title compound.

来源