反应 #93486

反应方程式

5-(5-chlorovaleryl)-2-benzyloxy-benzamide

1-phenylpiperazine

sodium carbonate

dimethyl sulfoxide

→

5-[5-(4-phenyl-1-piperazinyl)valeryl]-2-benzyloxy-benzamide

收率 84.3%

溶剂

water

反应条件

后处理

1. 1
   萃取the mixture was extracted with ethyl acetate
2. 2
   洗涤The extract was washed with water saturated with sodium chloride
3. 3
   干燥dried over anhydrous sodium sulfate
4. 4
   浓缩concentrated
5. 5
   workup.DISSOLUTIONThe thus produced residue was dissolved in acetone
6. 6
   workup.ADDITIONconcentrated hydrochloric acid in an amount of 2 equivalents was added
7. 7
   其他to produce crystals
8. 8
   过滤The crystals were filtered off

实验过程

A mixture of 2 g of 5-(5-chlorovaleryl)-2-benzyloxy-benzamide, 1 g of 1-phenylpiperazine, 0.6 g of sodium carbonate and 10 ml of dimethyl sulfoxide was heated at 90° C. for 6 hours while stirring. After the reaction was finished, water was added to the reaction mixture and the mixture was extracted with ethyl acetate. The extract was washed with water saturated with sodium chloride, dried over anhydrous sodium sulfate and concentrated. The thus produced residue was dissolved in acetone and concentrated hydrochloric acid in an amount of 2 equivalents was added thereto to produce crystals. The crystals were filtered off to obtain 2.3 g of 5-[5-(4-phenyl-1-piperazinyl)valeryl]-2-benzyloxy-benzamide (yield: 73%).

来源