反应 #933
ord-a610715a9a2049339b2b5008fb407eed
反应方程式
反应物
试剂
无
反应条件
详细条件
See reaction.notes.procedure_details.
后处理
- 1萃取The H2O solution was extracted with EtOAc
- 2干燥After drying over MgSO4 and solvent removal
- 3其他the resultant crude product was purified by flash column chromatography on silica gel with methylene chloride as the fluent
- 4其他This resulted in 1.15 g of 2-fluoro-6-[(3-methoxyphenyl)sulfonyl]benzonitrile as a solid
实验过程
To a solution of 2 g (7.7 mmol) of 2-fluoro-6-[(3-methoxyphenyl)thio]benzonitrile (Example 13) was added 2.93 g (17 mmol) of m-chloroperbenzoic acid. The resultant mixture was stirred for 24 h. Additional 0.29 g of m-chloroperbenzoic acid was added and the resultant mixture was stirred for 15 min. Excess sodium bisulfite was added, followed by water. The H2O solution was extracted with EtOAc. After drying over MgSO4 and solvent removal, the resultant crude product was purified by flash column chromatography on silica gel with methylene chloride as the fluent. This resulted in 1.15 g of 2-fluoro-6-[(3-methoxyphenyl)sulfonyl]benzonitrile as a solid: mp 113°-117° C.