反应 #93138

反应方程式

2,6-dinitrobenzonitrile

piperidine

water

→

2-nitro-6-piperidinobenzonitrile

溶剂

dimethylformamide

反应条件

后处理

1. 1
   温度while externally cooling because of heat generation
2. 2
   其他the precipitate thus formed
3. 3
   其他was collected
4. 4
   洗涤washed with water
5. 5
   干燥with methanol, and dried

实验过程

5.8 g of 2,6-dinitrobenzonitrile was dissolved in 30 ml of dimethylformamide, and 10.2 ml of piperidine was added to the solution. The mixture was stirred at 50° C. for 30 minutes while externally cooling because of heat generation. The reaction mixture was poured into water, and the precipitate thus formed was collected, washed with water and then with methanol, and dried to obtain 6.7 of 2-nitro-6-piperidinobenzonitrile (melting point: 122°-123° C.).

来源