反应 #92946

反应方程式

1,3-di-O-benzyl-2-O-chloromethylglycerol

sodium acetate

→

2-O-acetoxymethyl-1,3-di-O-benzylglycerol

溶剂

dimethlyformamide

反应条件

后处理

1. 1
   其他The solvent was removed by evaporation at reduced pressure
2. 2
   workup.DISSOLUTIONthe oily residue dissolved in 1 pound of diethylether
3. 3
   洗涤The ether solution was washed once with 750 ml of water, two times with 250 ml of water
4. 4
   干燥once with 250 ml of brine, dried over sodium sulfate
5. 5
   浓缩concentrated

实验过程

To a solution of 1,3-di-O-benzyl-2-O-chloromethylglycerol from Preparation II (17.5 g, 55 mmol) in 400 ml of dimethlyformamide at 0° C. under a drying tube was added sodium acetate (6 g). The solution was then warmed to 21° C. and magnetically stirred for 15 hours. The solvent was removed by evaporation at reduced pressure and the oily residue dissolved in 1 pound of diethylether. The ether solution was washed once with 750 ml of water, two times with 250 ml of water, and once with 250 ml of brine, dried over sodium sulfate and concentrated to give 19 g of 2-O-acetoxymethyl-1,3-di-O-benzylglycerol as an oil.

来源