反应 #929

反应方程式

2,6-dinitrobenzonitrile

thiophenol

K2CO3

Pyridine

→

2-nitro-6-(phenylthio)benzonitrile

收率 89.0%

溶剂

H2O

DMF

反应条件

后处理

1. 1
   过滤The yellow precipitate was collected by filtration
2. 2
   洗涤washed with 1N NaOH, water
3. 3
   其他dried

实验过程

An ice water bath-cooled mixture of 2.0 g (0.01 mol) of 2,6-dinitrobenzonitrile (Lancaster Synthesis, Inc., Windham, N.H. 03087), 1.06 ml (0.01 mol) of thiophenol, and 1.44 g (0.01 mol) of anhydrous K2CO3 in 50 mL of DMF was stirred for 0.5 h. Pyridine was added to the reaction mixture until it became basic, and was followed by the addition of approximately 100 mL of H2O. The yellow precipitate was collected by filtration, washed with 1N NaOH, water and dried to give 1.94 g (89%) of 2-nitro-6-(phenylthio)benzonitrile as a yellow solid: mp 106°-107° C.

来源