反应 #927263

反应方程式

ethanol

cyclopropene

sodium amide

8-Iodooct-1-ene

→

1-(oct-7-enyl)-cyclopropene

收率 67.0%

溶剂

ammonia

ammonia

Ether

ammonia

ammonia

反应条件

后处理

1. 1
   其他recooled to −78° C
2. 2
   温度the reaction mixture was warmed
3. 3
   温度to reflux for ½ hour
4. 4
   workup.DISTILLATIONto distill out of the reaction mixture
5. 5
   洗涤The reaction mixture was washed with water, 0.5M HCl (2×), water and brine
6. 6
   干燥It was dried over MgSO4
7. 7
   过滤filtered
8. 8
   其他The product was purified by chromatography on silica gel

实验过程

A mixture of 0.43 g (11 mmol) of sodium amide in roughly 15 ml of ammonia was cooled to −78° C. A chilled solution of cyclopropene in ammonia (1:1, 0.85 g, 10 mmol) was poured into the reaction mixture. The reaction mixture was stirred at −78° C. for ½ hour, warmed briefly to the ammonia boiling point, then recooled to −78° C. 8-Iodooct-1-ene (1.2 g, 5 mmol) was added by syringe, and the reaction mixture was warmed to reflux for ½ hour. A few ml of ethanol were added. Ether (25 ml) was slowly added while the ammonia was allowed to distill out of the reaction mixture. The reaction mixture was washed with water, 0.5M HCl (2×), water and brine. It was dried over MgSO4, filtered and stripped. The product was purified by chromatography on silica gel using hexane as the eluent. A 10 mg sample of 67% pure 1-(oct-7-enyl)-cyclopropene was obtained.

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