反应 #927259

反应方程式

hydrochloric acid

bromoform

2-pentyl-hept-1-ene

potassium t-butoxide

→

2,2-dibromo-1,1-dipentyl-cyclopropane

收率 83.4%

溶剂

water

—

pentanes

反应条件

后处理

1. 1
   workup.ADDITIONwas added slowly via addition funnel
2. 2
   其他The resulting mixture was transferred to a separatory funnel
3. 3
   其他the phases were separated
4. 4
   干燥The organic layer was dried over MgSO4
5. 5
   过滤filtered
6. 6
   其他The solvent was removed from the filtrate in vacuo

实验过程

To a solution of 4.16 g (0.0247 mol) of 2-pentyl-hept-1-ene in 31 ml of pentanes, was added 4.95 g (0.0441 mol) of potassium t-butoxide. While cooling the resulting mixture to an internal temperature of 5° C., 4.01 ml ( 0.0459 mol) of bromoform was added slowly via addition funnel. The reaction mixture was allowed to warm naturally to room temperature and left overnight. To the reaction mixture was added 25 ml of water then 36 ml of 1 N hydrochloric acid. The resulting mixture was transferred to a separatory funnel and the phases were separated. The organic layer was dried over MgSO4 and filtered. The solvent was removed from the filtrate in vacuo to yield 7.00 g (83.4% of theory) of 2,2-dibromo-1,1-dipentyl-cyclopropane as an oil.

来源