反应 #927255

反应方程式

hexane

sodium hydroxide

hexanol

2,3-dibromopropene

→

2-bromo-3-hexyloxypropene

收率 95.0%

溶剂

water

反应条件

后处理

1. 1
   其他To a three neck round bottom flask equipped with an addition funnel and an overhead stirrer
2. 2
   其他were fed to the well-stirred reaction mixture over a 20 minute period
3. 3
   其他the phases were separated
4. 4
   洗涤The organic phase was washed with water and brine
5. 5
   干燥dried over magnesium sulfate
6. 6
   过滤filtered
7. 7
   workup.DISTILLATIONThe product was fractionally distilled under reduced pressure

实验过程

To a three neck round bottom flask equipped with an addition funnel and an overhead stirrer was added 35 ml of hexane, 42 g of 50% sodium hydroxide and 0.50 g of tetra-n-butylammonium bromide. A mixture of 6.74 g of hexanol (66 mmol) and 20 g (100 mmol) of 2,3-dibromopropene were fed to the well-stirred reaction mixture over a 20 minute period. The reaction was stirred an additional 1 hour, then water was added, and the phases were separated. The organic phase was washed with water and brine, dried over magnesium sulfate, filtered and stripped. The product was fractionally distilled under reduced pressure to give 6.1 g of 95% pure 2-bromo-3-hexyloxypropene.

来源