反应 #927250

反应方程式

1,1,2-Tribromo-2-(7-hydroxyheptyl)cyclopropane

Water

→

7-(1,1,2-tribromo-cyclopropyl)-heptanoic acid

溶剂

acetic acid

acetic acid

反应条件

后处理

1. 1
   workup.ADDITIONwas added
2. 2
   萃取The solution was extracted with ether
3. 3
   萃取The ether phase was extracted three times with 1N NaOH solution
4. 4
   workup.ADDITIONA little sodium bisulfite was added
5. 5
   萃取extracted with ether twice
6. 6
   洗涤The ether extracts were washed with brine
7. 7
   干燥dried over magnesium sulfate

实验过程

1,1,2-Tribromo-2-(7-hydroxyheptyl)cyclopropane (0.90 g, 2.3 mmol) was dissolved in 60 ml of glacial acetic acid. A solution of 1.0 g (10 mmol) of chromium trioxide dissolved in 14 ml of 90% aqueous acetic acid was added and the reaction mixture was stirred at room temperature for 24 hours. Water (300 ml) was added. The solution was extracted with ether. The ether phase was extracted three times with 1N NaOH solution. A little sodium bisulfite was added. The aqueous extracts were acidified with 6N HCl, and extracted with ether twice. The ether extracts were washed with brine, dried over magnesium sulfate and stripped to give 0.56 g 7-(1,1,2-tribromo-cyclopropyl)-heptanoic acid.

来源