反应 #927248

反应方程式

1,1,2-tribromo-2-(7-hydroxyheptyl)cyclopropane

methyllithium

→

1-(7-hydroxyheptyl)-cyclopropene

收率 90.0%

溶剂

ether

反应条件

后处理

1. 1
   其他The reaction was quenched with saturated ammonium chloride
2. 2
   洗涤The reaction mixture was washed with water and brine
3. 3
   干燥dried over magnesium sulfate
4. 4
   过滤filtered

实验过程

A solution of 1.0 g 1,1,2-tribromo-2-(7-hydroxyheptyl)cyclopropane (2.5 mmol) in 25 ml of ether was treated at −78° C. with 7.2 ml of methyllithium (1.4 M, 10 mmol). After 5 minutes, the reaction mixture was warmed to 0° C. and held at this temperature. The reaction was quenched with saturated ammonium chloride. The reaction mixture was washed with water and brine, dried over magnesium sulfate, filtered and stripped to give 240 mg of 1-(7-hydroxyheptyl)-cyclopropene (90% purity).

来源