反应 #927246

反应方程式

toluenesulfonic acid

6-bromohexanol

ethyl vinyl ether

→

pale yellow liquid

1-(1-Ethoxyethoxy)-6-bromohexane

溶剂

ether

反应条件

后处理

1. 1
   其他by separate additional funnels
2. 2
   其他was kept at 7° C.
3. 3
   workup.ADDITIONroughly 1 ml of triethylamine was added
4. 4
   洗涤The reaction mixture was washed with water and brine
5. 5
   干燥dried over potassium carbonate
6. 6
   过滤filtered

实验过程

To a cooled solution of 80 mg of toluenesulfonic acid in 40 ml of ether was fed 20 g (110 mmol) of 6-bromohexanol and 40 ml of ethyl vinyl ether simultaneously by separate additional funnels. The temperature of the reaction mixture was kept at 7° C. or lower during the feeds, which took 1 hour. The reaction mixture was stirred 20 minutes longer, then roughly 1 ml of triethylamine was added. The reaction mixture was washed with water and brine, dried over potassium carbonate, filtered and stripped to give 25.7 g of a pale yellow liquid, which was used without further purification.

来源