反应 #927230

反应方程式

t-Butyl ethyl malonate

1,3-dibromo-5,5-dimethylhydantoin

→

light yellow oil

收率 176.5%

t-butyl ethyl bromomalonate

收率 176.5%

溶剂

toluene

反应条件

后处理

1. 1
   温度The reaction was cooled
2. 2
   浓缩concentrated
3. 3
   洗涤The organic layer was washed, with sat. NaHCO3 (2×), brine (3×)
4. 4
   干燥dried (MgSO4)
5. 5
   过滤filtered
6. 6
   浓缩concentrated
7. 7
   其他Purification
8. 8
   过滤by filtration on silica (70:30; hept:EtOAc)

实验过程

t-Butyl ethyl malonate (25.00 g, 0.13 mol) was dissolved in toluene and warmed to 80° C. To the resulting solution was added 1,3-dibromo-5,5-dimethylhydantoin (25.00 g, 0.07 mol). The reaction was stirred at elevated (80° C.) temperature 18 h. The reaction was cooled concentrated and taken up in Et2O. The organic layer was washed, with sat. NaHCO3 (2×), brine (3×), dried (MgSO4), filtered and concentrated. Purification by filtration on silica (70:30; hept:EtOAc) yielded 33.0 g (93%) of a light yellow oil. NMR and MS indicated a mixture of three compounds SM (20%), monobrominated (55%) and dibromonated diesters (25%). The material was used without further purification.

来源