反应 #924

反应方程式

methyl chloroformate

N-(1,1-dimethylethyl)-1-methyl-1H-pyrrole-2-sulfonamide

n-butyllithium

→

title compound

收率 14.3%

Methyl 2-[[(1,1-Dimethylethyl)amino]sulfonyl]-1-methyl-1H-pyrrole-3-carboxylate

收率 14.3%

溶剂

THF

ethyl acetate

THF

反应条件

后处理

1. 1
   其他the temperature below -58° C
2. 2
   其他1 h
3. 3
   其他at 0° C.
4. 4
   其他was recooled to -70° C.
5. 5
   workup.STIRRINGThe reaction mixture was stirred overnight at ambient temperature
6. 6
   洗涤This solution was washed successively with two 60 mL portions of 1N HCl, brine
7. 7
   干燥dried (Na2SO4)
8. 8
   其他evaporated to a dark oil
9. 9
   其他The crude product was purified by chromatography on silica gel (30% ethyl acetate/70% hexanes)
10. 10
    其他then collected from hexanes

实验过程

To a solution of 2.5 g (11.5 mmol) of N-(1,1-dimethylethyl)-1-methyl-1H-pyrrole-2-sulfonamide in 50 mL THF under nitrogen atmosphere cooled to below -70° C. was added dropwise 13 mL (32.5 mmol) of 2.5M n-butyllithium at such a rate as to keep the temperature below -58° C. After stirring at -20° C. to -10° C. for 30 min then 1 h at 0° C., the mixture was recooled to -70° C. and treated with a solution of 1.63 g (17.3 mmol) of methyl chloroformate in 6 mL THF causing an exotherm to -57° C. The reaction mixture was stirred overnight at ambient temperature then diluted with 200 mL of ethyl acetate. This solution was washed successively with two 60 mL portions of 1N HCl, brine, then dried (Na2SO4) and evaporated to a dark oil. The crude product was purified by chromatography on silica gel (30% ethyl acetate/70% hexanes) then collected from hexanes to afford 0.45 g of the title compound, m.p. 105°-108° C.

来源