反应 #92324

反应方程式

t-Butyl {[(1R,2R,5S)-5-(dimethylcarbamoyl)-2-hydroxycyclohexyl]sulfamoyl}carbamate

p-toluenesulfonyl chloride

N-methylimidazole

→

title compound

收率 38.0%

(1R,2R,4S)-2-{[(t-Butoxycarbonyl) sulfamoyl]amino}-4-(dimethylcarbamoyl)cyclohexyl 4-methylbenzenesulfonate

收率 38.0%

溶剂

dichloromethane

反应条件

后处理

1. 1
   其他Thereafter, the reaction mixture was purified by silica gel column chromatography

实验过程

t-Butyl {[(1R,2R,5S)-5-(dimethylcarbamoyl)-2-hydroxycyclohexyl]sulfamoyl}carbamate (200 mg) was dissolved in dichloromethane (2.0 mL), and p-toluenesulfonyl chloride (136 mg) and N-methylimidazole (87.0 mL) were then added to the obtained solution. The obtained mixture was stirred at room temperature for approximately 20 hours. Thereafter, the reaction mixture was purified by silica gel column chromatography to obtain the title compound (107 mg, yield: 38%) in the form of powder.

来源