反应 #920

反应方程式

(1,1-dimethylethyl)-N2,N2,1-trimethyl-1H-pyrrole-2,3-disulfonamide

TFA

→

title compound

N2,N2,1-Trimethyl-1H-pyrrole-2,3-disulfonamide

溶剂

methylene chloride

反应条件

后处理

1. 1
   浓缩The reaction mixture was concentrated in vacuo
2. 2
   workup.ADDITIONThree portions of diethyl ether were added to the solid residue
3. 3
   其他removed by evaporation
4. 4
   其他to remove residual TFA
5. 5
   过滤filtered

实验过程

To a solution of 6.95 g (21 mmol) of N3 -(1,1-dimethylethyl)-N2,N2,1-trimethyl-1H-pyrrole-2,3-disulfonamide in 75 mL of methylene chloride under a nitrogen atmosphere was added 75 mL of TFA. The reaction mixture was allowed to stir at room temperature overnight ca. 16 hours. The reaction mixture was concentrated in vacuo. Three portions of diethyl ether were added to the solid residue and removed by evaporation to remove residual TFA. The solids were suspended in diethyl ether and filtered to yield 4.52 g of the title compound as a solid, m.p. 146°-148° C.

来源