反应 #91960

反应方程式

thiazole-2-carboxamidine

2-bromo-4-fluorobenzaldehyde

5-methyl-oxazole-4-carboxamidine

(S)-4,4-difluoro-pyrrolidine-2-carboxylic acid

(S)-morpholine-3-carboxylic acid

→

title compound

(S)-4-[(R)-6-(2-Bromo-4-fluoro-phenyl)-5-methoxycarbonyl-2-(5-methyl-oxazol-4-yl)-3,6-dihydro-pyrimidin-4-ylmethyl]-morpholine-3-carboxylic acid

反应条件

实验过程

The title compound was prepared in analogy to Example 2 with Procedure A shown in Scheme 4 by using 2-bromo-4-fluorobenzaldehyde, 5-methyl-oxazole-4-carboxamidine (Compound AB) and (S)-morpholine-3-carboxylic acid instead of 2-chloro-4-fluorobenzaldehyde, thiazole-2-carboxamidine and (S)-4,4-difluoro-pyrrolidine-2-carboxylic acid. The stereochemistry of Example 65 was determined by comparing its 1H NMR data and HPLC retention time with Example 2.

来源