反应 #91908

反应方程式

5-oxo-5,6,7,8-tetrahydronaphthalen-2-yl trifluoromethanesulfonate

3-methylbenzene-1-thiol

DIEA

→

title compound

收率 110.0%

6-[(3-methylphenyl)sulfanyl]-1,2,3,4-tetrahydronaphthalen-1-one

收率 110.0%

溶剂

1,4-dioxane

反应条件

后处理

1. 1
   温度at reflux overnight under N2
2. 2
   过滤The reaction was filtered
3. 3
   浓缩concentrated
4. 4
   其他Purification by silica gel chromatography (PE:EtOAc=5:1)

实验过程

The suspension of 5-oxo-5,6,7,8-tetrahydronaphthalen-2-yl trifluoromethanesulfonate (1.8 g, 6.1 mmol), 3-methylbenzene-1-thiol (0.76 g, 6.1 mmol), Pd2(dba)3 (142 mg, 0.153 mmol), Xantphos (177 mg, 0.306 mmol) and DIEA (1.58 g, 12.2 mmol) in 1,4-dioxane (60 mL) was stirred at reflux overnight under N2. The reaction was filtered and concentrated. Purification by silica gel chromatography (PE:EtOAc=5:1) gave 1.8 g (100%) of the title compound as an orange oil. [M+H] Calc'd for C17H16OS, 269. Found, 269.

来源