反应 #91671

反应方程式

2-bromopyridin-3-ol

pyrrolidine

HCl

→

2-(pyrrolidin-1-yl)pyridin-3-ol

收率 41.3%

反应条件

后处理

1. 1
   萃取extracted with ethyl acetate and dichloromethane
2. 2
   干燥The obtained organic layer was dried over magnesium sulfate
3. 3
   浓缩concentrated under reduced pressure
4. 4
   其他The concentrate was purified by column chromatography

实验过程

2-bromopyridin-3-ol (200 mg, 1.15 mmol) and pyrrolidine (184 mg, 2.58 mmol) were added in a reaction tube, followed by reacting in microwave at 120° C. for 20 minutes. The reaction mixture was added with 1 M HCl solution to neutralized, and extracted with ethyl acetate and dichloromethane. The obtained organic layer was dried over magnesium sulfate, and concentrated under reduced pressure. The concentrate was purified by column chromatography to obtain 2-(pyrrolidin-1-yl)pyridin-3-ol (78 mg, 41%).

来源