反应 #91656

反应方程式

2-Bromopyridin-3-ol

3-furan boronic acid

sodium carbonate

→

2-(furan-3-yl)pyridin-3-ol

收率 27.0%

溶剂

dimethoxyethane water

反应条件

后处理

1. 1
   其他After the completion of the reaction
2. 2
   过滤the reaction mixture was filtered
3. 3
   workup.ADDITIONThe filtrate was added with water
4. 4
   萃取extracted with ethyl acetate
5. 5
   干燥The obtained organic layer was dried over magnesium sulfate
6. 6
   其他purified by column chromatography (ethyl acetate:hexane=1:3)

实验过程

2-Bromopyridin-3-ol (200 mg, 1.15 mmol), 3-furan boronic acid (574 mg, 1.38 mmol), sodium carbonate (365 mg, 12.8 mmol) and Pd2(dppf)2Cl2 (187 mg, 0.23 mmol) were dissolved in dimethoxyethane/water 2 mL/1 mL, followed by stirring in microwave at 120° C. for 20 minutes. After the completion of the reaction, the reaction mixture was filtered using Celite. The filtrate was added with water, and extracted with ethyl acetate. The obtained organic layer was dried over magnesium sulfate, and purified by column chromatography (ethyl acetate:hexane=1:3) to obtain 2-(furan-3-yl)pyridin-3-ol (50 mg, 27%).

来源