反应 #911

反应方程式

methyl 3-[[(1,1-dimethylethyl)amino]-sulfonyl]-1-methyl-1H-pyrrole-2-carboxylate

trifluoroacetic acid

→

title compound

Methyl 3-(aminosulfonyl)-1-methyl-1H-pyrrole-2-carboxylate

溶剂

methylene chloride

反应条件

后处理

1. 1
   浓缩The gold solution was concentrated to an oily residue
2. 2
   workup.ADDITIONDiethyl ether was added to the residue
3. 3
   其他removed by evaporation
4. 4
   其他to remove residual TFA
5. 5
   过滤filtered

实验过程

To a solution of 3.53 g of methyl 3-[[(1,1-dimethylethyl)amino]-sulfonyl]-1-methyl-1H-pyrrole-2-carboxylate in 40 mL, of methylene chloride under an nitrogen atmosphere was added 80 mL of trifluoroacetic acid (TFA). The gold solution was stirred at room temperature overnight ca. 16 hours. The gold solution was concentrated to an oily residue. Diethyl ether was added to the residue and removed by evaporation to remove residual TFA. The resulting solid was suspended in diethyl ether and filtered affording the title compound as a tan solid, m.p. 105°-107° C.

来源