反应 #91022

反应方程式

Methyl 4-(benzyloxy)-3-chloro-5-isopropoxybenzoate

→

methyl 3-chloro-4-hydroxy-5-isopropoxybenzoate

收率 92.6%

Methyl 3-chloro-4-hydroxy-5-isopropoxybenzoate

收率 92.6%

溶剂

MeOH

DCM

AcOH

反应条件

后处理

1. 1
   其他at 25° C.
2. 2
   其他The solvents were removed in vacuo

实验过程

Methyl 4-(benzyloxy)-3-chloro-5-isopropoxybenzoate (2) (3.00 g, 8.96 mmol) was dissolved in a mixture of MeOH (100 mL), DCM (10 mL) and AcOH (0.1 mL) and the solution was passed through a Thales ‘H-cube’ cartridge (10% Pd/C) at a flow rate of 1 mL/min at 25° C. under H2 (full H2 mode). The solvents were removed in vacuo to afford methyl 3-chloro-4-hydroxy-5-isopropoxybenzoate (3) (2.03 g, 89%): m/z 245 [M+H]+ (ES+), 243 [M−H](ES−).

来源