反应 #9064

反应方程式

4-(Benzimidazol-2-yl)-benzyl alcohol

→

4-(benzimidazol-2-yl)-benzaldehyde

收率 42.0%

溶剂

CH2Cl2

THF

反应条件

后处理

1. 1
   过滤The mixture was filtered through celite
2. 2
   洗涤the cake washed with CH2Cl2
3. 3
   其他the solvent from the eluent removed under reduced pressure

实验过程

4-(Benzimidazol-2-yl)-benzyl alcohol from above (0.175 g, 0.78 mmol) was dissolved in CH2Cl2 (5 mL) and THF (8 mL), treated with activated MnO2 (0.68 g, 7.8 mmol) and stirred at room temperature for 1.5 h. The mixture was filtered through celite, the cake washed with CH2Cl2 and the solvent from the eluent removed under reduced pressure to afford 4-(benzimidazol-2-yl)-benzaldehyde (92 mg, 42%). 1H NMR (CD4OD) δ 7.28 (m, 2H), 7.60 (br, 1H (NH)), 7.65 (d, 2H, J=7.8 Hz), 8.09 (d, 2H, J=7.8 Hz), 8.30 (d, 2H, J=9.0 Hz), 10.08 (s, 1H (CHO)).

来源