反应 #9045

反应方程式

alcohol

N, N′-bis-(tert-butoxycarbonyl)-N″-(4-hydroxymethyl-phenyl)-guanidine

→

N, N′-bis-(tert-butoxycarbonyl)-N″-(4-formyl-phenyl)-guanidine

收率 93.0%

溶剂

CH2Cl2

反应条件

后处理

1. 1
   过滤The mixture was filtered through celite®
2. 2
   洗涤the cake was washed with CH2Cl2
3. 3
   其他The solvent was removed from the filtrate under reduced pressure

实验过程

The alcohol (0.282 g, 0.771 mmol) from above was dissolved in CH2Cl2 (7 mL), treated with activated MnO2 (0.696 g, 8.01 mmol) and stirred at room temperature overnight. The mixture was filtered through celite® and the cake was washed with CH2Cl2. The solvent was removed from the filtrate under reduced pressure and provided N, N′-bis-(tert-butoxycarbonyl)-N″-(4-formyl-phenyl)-guanidine (0.260 g, 93%) as a white solid. 1H NMR (CDCl3) δ 1.53 (s, 9H), 1.55 (s, 9H), 7.85 (s, 4H), 9.93 (s, 1H), 10.34 (br s, 1H).

来源