反应 #9007

反应方程式

alcohol

[2-(4-Hydroxymethyl-phenyl)-ethyl]-carbamic acid tert-butyl ester

→

aldehyde

收率 88.0%

[2-(4-Formyl-phenyl)-ethyl]-carbamic acid tert-butyl ester

收率 88.0%

溶剂

CH2Cl2

反应条件

后处理

1. 1
   过滤The reaction mixture was filtered through Celite
2. 2
   洗涤the cake was washed with CH2Cl2
3. 3
   其他The solvent was removed from the filtrate under reduced pressure

实验过程

To a solution of the alcohol from above (200 mg, 0.796 mmol) in CH2Cl2 (8 mL) was added activated MnO2 (814 mg, 7.96 mmol) and the mixture stirred at room temperature for 69 h. The reaction mixture was filtered through Celite and the cake was washed with CH2Cl2. The solvent was removed from the filtrate under reduced pressure to give the desired aldehyde as colourless crystals (175 mg, 88%). 1H NMR (CDCl3) δ 1.43 (s, 9H), 2.89 (m, 2H), 3.41 (m, 2H), 4.55 (br s, 1H), 7.37 (d, 2H, J=8.1 Hz), 7.83 (d, 2H, J=7.8 Hz), 9.99 (s, 1H).

来源