反应 #899

反应方程式

m-(trifluoromethyl)phenol

NaH

4,6-dibromo-2-(methylthio)pyrimidine

→

phenoxide

4-bromo-2-methylthio-6-[3-(trifluoromethyl)phenoxy]pyrimidine

溶剂

THF

反应条件

后处理

1. 1
   workup.ADDITIONVII-22) (2.0 g, 0.00794 mol) was added
2. 2
   其他to react for 5 hours at room temperature

实验过程

In THF, a phenoxide was prepared from m-(trifluoromethyl)phenol (1.30 g, 0.00794×1.0 mol) and NaH (0.32 g (ca. 60% in mineral oil), 0.00794×1.0 mol), and 4,6-dibromo-2-(methylthio)pyrimidine (Compound No. VII-22) (2.0 g, 0.00794 mol) was added thereto, and the mixture was then allowed to react for 5 hours at room temperature.

来源