反应 #8802

反应方程式

Ester

methyl 2-(3-tert-butyloxycarbonylamino-4-thienyl)-4,5-dihydroxypyrimidine-6-carboxylate

trifluoroacetic acid

→

methyl 2-(3-amino-4-thienyl)-4,5-dihydroxy-pyrimidine-6-carboxylate trifluoroacetate

收率 99.0%

溶剂

methylene chloride

反应条件

后处理

1. 1
   浓缩then concentrated in vacuo
2. 2
   其他the residue dried

实验过程

Ester 40 (828 mg, 2.25 mmol), prepared as described above, was treated with a 6:4 mixture of methylene chloride:trifluoroacetic acid (8 ml). The solution was stirred for 20 min then concentrated in vacuo and the residue dried to give methyl 2-(3-amino-4-thienyl)-4,5-dihydroxy-pyrimidine-6-carboxylate trifluoroacetate (860 mg, 99%) as a solid. 1H NMR (DMSO-d6): δ 8.32 (1H, s), 6.75 (1H, s), 3.87 (3H, s). MS m/z (MH)+ 268.0.

来源