反应 #87602

反应方程式

2-chloro-5-((2,2,2-trifluoroacetamido)methyl)benzoic acid

HCl

→

5-(aminomethyl)-2-chlorobenzoic acid hydrochloride

溶剂

methanol

反应条件

后处理

1. 1
   温度The reaction mixture was refluxed for 18 h
2. 2
   浓缩The reaction mixture was concentrated
3. 3
   其他crude reaction mixture

实验过程

To a solution of 2-chloro-5-((2,2,2-trifluoroacetamido)methyl)benzoic acid (step-1 of Intermediate-26, 10.0 g, 35.50 mmol) in methanol (100 mL) was added conc. HCl (10 mL). The reaction mixture was refluxed for 18 h. The reaction mixture was concentrated and crude reaction mixture was used for next step.

来源