反应 #869

反应方程式

HCl dioxane

N-t-butoxycarbonyl-(R)-α-methoxymethylbenzylamine

→

(R)-α-methoxymethylbenzylamine hydrochloride

反应条件

后处理

1. 1
   浓缩The reaction mixture was concentrated under reduced pressure
2. 2
   workup.ADDITION30 ml of ether were added to the residue
3. 3
   浓缩this was further concentrated

实验过程

60 ml of 4N-HCl/dioxane solution was added to 4.02 g (16.0 mmols) of N-t-butoxycarbonyl-(R)-α-methoxymethylbenzylamine, and the mixture was stirred at room temperature for one hour. The reaction mixture was concentrated under reduced pressure. 30 ml of ether were added to the residue, and this was further concentrated to obtain (R)-α-methoxymethylbenzylamine hydrochloride in quantitative yield.

来源