反应 #860

反应方程式

2-(2-methoxyethoxy)ethylamine

acetic acid

acetate

cyanamide

→

title compound

收率 28.5%

2-(2-methoxyethoxy)ethylguanidine

收率 28.5%

溶剂

反应条件

后处理

1. 1
   其他After 5 hours of the reaction
2. 2
   其他the product was purified by a silica gel column chromatography (eluent, chloroform/ethanol=2/1 containing 0.5% acetic acid)

实验过程

5.96 g (50.0 mmol) of 2-(2-methoxyethoxy)ethylamine and 3.00 g (50.0 mmol) of acetic acid were placed in a 30 ml two neck flask. While heating the flask in a 90° C. oil bath, 3.10 g (73.7 mmol) of cyanamide was added. After 5 hours of the reaction, the product was purified by a silica gel column chromatography (eluent, chloroform/ethanol=2/1 containing 0.5% acetic acid) to obtain 3.15 g of the title compound (wax-like, 14.2 mmol, 28.5% in yield) in the form of acetate. Results of the analysis of this compound are as follows.

来源