反应 #8527

反应方程式

hydrogen

2,3,4-Trifluoroaniline

methyl pyruvate

magnesium sulfate

→

title compound

收率 95.3%

Methyl 2-(2,3,4-trifluoroanilino)propionate

收率 95.3%

溶剂

methanol

反应条件

后处理

1. 1
   过滤After filtering off Pd—C and magnesium sulfate
2. 2
   浓缩the obtained filtrate was concentrated under reduced pressure
3. 3
   其他The crystals thus precipitated
4. 4
   过滤were filtered
5. 5
   洗涤while washing with hexane

实验过程

2,3,4-Trifluoroaniline (2.94 g) and methyl pyruvate (2.04 g) were dissolved in methanol (30 ml). After adding 5% Pd—C (2.0 g) and anhydrous magnesium sulfate (2.65 g), the mixture was stirred at 50° C. in a hydrogen atmosphere for 16 hours. After filtering off Pd—C and magnesium sulfate, the obtained filtrate was concentrated under reduced pressure. The crystals thus precipitated were filtered while washing with hexane. Thus the title compound (4.44 g) was obtained as slightly yellowish crystals. Various spectral data of this product was identical with those obtained in Example 5.

来源