反应 #8490

反应方程式

5-fluoro-2-methylbenzonitrile

N-bromosuccinimide

→

product

收率 102.0%

2-Bromomethyl-5-fluorobenzonitrile

收率 102.0%

溶剂

carbon tetrachloride

反应条件

后处理

1. 1
   温度was refluxed for 18 h
2. 2
   过滤filtered through fritted glass
3. 3
   洗涤The solid in the funnel was washed with carbon tetrachloride (3×50 mL)
4. 4
   其他evaporated to dryness under vacuum

实验过程

A mixture of 5-fluoro-2-methylbenzonitrile (10.0 g, 74.0 mmol), N-bromosuccinimide (NBS, 13.2 g, 74.0 mmol), benzoyl peroxide (0.2 g, 0.82 mmol), and carbon tetrachloride (100 mL) was refluxed for 18 h. The reaction mixture was then cooled to room temperature and filtered through fritted glass. The solid in the funnel was washed with carbon tetrachloride (3×50 mL) and evaporated to dryness under vacuum to provide 16.1 g, 102% yield of product.

来源