反应 #8465

反应方程式

product

alpha-bromo-2′-methyl-4′-chloropropoxyacetophenone

2-amino-4-picoline

→

2-(4′-chloropropoxy-2′-methylphenyl)-7-methylimidazo[1,2-a]pyridine

溶剂

ethanol

methanol dichloromethane

反应条件

后处理

1. 1
   其他The resin was removed via filtration
2. 2
   其他the filtrate evaporated
3. 3
   其他The title compound was precipitated from ethyl acetate upon addition of hexanes
4. 4
   其他used without further purification

实验过程

A solution of the product of Step B (6.77 g) and 2-amino-4-picoline (2.4 g) in ethanol (22 mL) was heated at 72° C. for 10 hours. The reaction mixture was cooled to ambient temperature and dissolved in methanol/dichloromethane and treated with Dowex® 550A basic resin until the pH of the mixture was 7. The resin was removed via filtration and the filtrate evaporated. The title compound was precipitated from ethyl acetate upon addition of hexanes and used without further purification.

来源