反应 #8464

反应方程式

sodium bicarbonate

product

2′-methyl-4′-chloropropoxyacetophenone

bromine

→

title compound

alpha-bromo-2′-methyl-4′-chloropropoxyacetophenone

溶剂

ether

反应条件

后处理

1. 1
   其他the organic layer was separated
2. 2
   洗涤The aqueous layer was washed with a fresh portion of ether (100 mL)
3. 3
   洗涤The combined organic layers were washed with a fresh portion of water (100 mL)
4. 4
   干燥dried over magnesium sulfate
5. 5
   过滤filtered
6. 6
   其他evaporated

实验过程

A solution of the product of Step A (9.33 g) in ether (42 mL) was treated with bromine (2.1 mL) and the mixture stirred for approximately 17 hours. The mixture was slowly poured into saturated sodium bicarbonate solution (100 mL) and then the organic layer was separated. The aqueous layer was washed with a fresh portion of ether (100 mL). The combined organic layers were washed with a fresh portion of water (100 mL), dried over magnesium sulfate, filtered and evaporated to give the title compound (11 g).

来源