反应 #84283

反应方程式

1-(3-chloro-5-methoxypyridin-2-yl)ethanone

trimethylphenylammonium tribromide

→

desired product

收率 76.8%

2-bromo-1-(3-chloro-5-methoxypyridin-2-yl)ethanone

收率 76.8%

溶剂

tetrahydrofuran

反应条件

后处理

1. 1
   其他After completion of the reaction
2. 2
   过滤the precipitated solid was filtered off
3. 3
   其他the solvent was evaporated under reduced pressure
4. 4
   其他The resulting residue was purified by silica gel column chromatography

实验过程

To 0.90 g of 1-(3-chloro-5-methoxypyridin-2-yl)ethanone in 10 ml of tetrahydrofuran, 1.82 g of trimethylphenylammonium tribromide was added, and the mixture was stirred at room temperature for 16 hours. After completion of the reaction, the precipitated solid was filtered off, and the solvent was evaporated under reduced pressure. The resulting residue was purified by silica gel column chromatography using ethyl acetate-hexane (with a gradient of from 1:9 to 3:7) as the eluent to obtain 0.57 g of the desired product as pale yellow crystals.

来源