反应 #84101

反应方程式

2-chloro-4-fluoro-6-methoxyquinoline

BBr3

→

product

收率 69.0%

2-chloro-4-fluoroquinolin-6-ol

收率 69.0%

溶剂

DCM

反应条件

后处理

1. 1
   萃取Aqueous workup with DCM extraction
2. 2
   其他gave the crude product, which
3. 3
   其他was purified by silica gel column (PE/EtOAc=50/1)

实验过程

A mixture solution of 2-chloro-4-fluoro-6-methoxyquinoline (see U.S. 61/391,225 for synthesis) (280 mg, 1.32 mmol) and BBr3 (0.3 mL, 3.2 mmol, 2.64 g/mL) in DCM (5 mL) was stirred at 20° C. for 12 hours. Aqueous workup with DCM extraction gave the crude product, which was purified by silica gel column (PE/EtOAc=50/1) to give product (177 mg, yield 69%) as a white solid.

来源