反应 #84069

反应方程式

4-(6-hydroxyquinolin-2-yl)benzonitrile

NH2OH.HCl

→

desired product

收率 78.0%

N-hydroxy-4-(6-hydroxyquinolin-2-yl)benzimidamide

收率 78.0%

溶剂

EtOH

反应条件

后处理

1. 1
   浓缩followed by concentration in vacuo
2. 2
   workup.STIRRINGstirred for 1 hour
3. 3
   过滤Filtration
4. 4
   其他drying of the solids

实验过程

See Scheme 4, route B. 4-(6-hydroxyquinolin-2-yl)benzonitrile (900 mg, 3.68 mmol) was dissolved in 25 mL of EtOH and to it was added NH2OH.HCl (500 mg, 7.36 mmol) and TEA (1.5 mL). The mixture was stirred at 80° C. for 2 hours followed by concentration in vacuo. The crude solids were then suspended in 25 mL of H2O and stirred for 1 hour. Filtration and drying of the solids yielded desired product (800 mg, 78% yield).

来源