反应 #84066

反应方程式

4-cyanophenylboronic acid

2,4-dichloro-6-methoxyquinoline

→

desired product

4-(4-chloro-6-methoxyquinolin-2-yl)benzonitrile

溶剂

DMF

反应条件

后处理

1. 1
   温度to cool
2. 2
   其他The resulting solid was isolated by filtration
3. 3
   洗涤washed with water
4. 4
   其他dried
5. 5
   其他followed by recrystallization from methanol

实验过程

Followed Scheme 2, Step 1 starting from 4-cyanophenylboronic acid and 2,4-dichloro-6-methoxyquinoline, where the solvent used was DMF, and the catalyst used was Pd(PPh3)4. The mixture was heated to 100° C. for 3 h, allowed to cool, and then poured into ice water. The resulting solid was isolated by filtration, washed with water, and dried followed by recrystallization from methanol to give the desired product.

来源