反应 #84050

反应方程式

pentafluorophenol

EDC

1-azabicyclo[2.2.2]oct-3-ylacetic acid hydrochloride

→

Pentafluorophenyl (1-azabicyclo[2.2.2]oct-3-yl)acetate hydrochloride

溶剂

dichloromethane

反应条件

后处理

1. 1
   浓缩The contents of the flask are concentrated in vacuo
2. 2
   其他dried under high vacuum
3. 3
   其他The resulting crude product is employed without further purification in the following stages

实验过程

358 mg (1.94 mmol) of pentafluorophenol, 120.5 mg (0.63 mmol) of EDC and 1 drop of N,N-diisopropylethylamine are added to a solution of 100 mg (0.49 mmol) of 1-azabicyclo[2.2.2]oct-3-ylacetic acid hydrochloride in 4 ml of dichloromethane at 0° C. The mixture is stirred at room temperature for 18 h. The contents of the flask are concentrated in vacuo and dried under high vacuum. The resulting crude product is employed without further purification in the following stages.

来源