反应 #84049

反应方程式

methyl 6-bromo-1-benzothiophene-2-carboxylate

potassium hydroxide

→

desired product

6-Bromo-1-benzothiophene-2-carboxylic acid

溶剂

THF

反应条件

后处理

1. 1
   其他The solvent is removed in vacuo
2. 2
   过滤The resulting precipitate is filtered off with suction
3. 3
   洗涤washed with water
4. 4
   其他dried in vacuo at 50° C

实验过程

A solution of 4.0 g (14.8 mmol) of methyl 6-bromo-1-benzothiophene-2-carboxylate in 40 ml of a 1:1 mixture of THF and 2 N potassium hydroxide solution is stirred at room temperature for 2 h. The solvent is removed in vacuo, and the residue is acidified with concentrated hydrochloric acid. The resulting precipitate is filtered off with suction, washed with water and dried in vacuo at 50° C. 3.55 g (93.5% of theory) of the desired product are obtained.

来源