反应 #84048

反应方程式

quinuclidin-3-one hydrochloride

sodium methoxide

→

title compound

Quinuclidin-3-one

溶剂

methanol

methanol

反应条件

后处理

1. 1
   过滤The resulting precipitate is filtered off with suction
2. 2
   浓缩the filtrate is concentrated in vacuo
3. 3
   其他The residue is partitioned between chloroform and water
4. 4
   萃取extracted with chloroform
5. 5
   干燥The combined organic phases are dried over sodium sulfate
6. 6
   浓缩concentrated in vacuo

实验过程

100 g (0.62 mol) of quinuclidin-3-one hydrochloride are suspended in 2 l of methanol. At 0° C., a solution of 33.4 g (0.62 mol) of sodium methoxide in 250 ml of methanol is slowly added dropwise. The mixture is stirred at room temperature for 16 h. The resulting precipitate is filtered off with suction, and the filtrate is concentrated in vacuo. The residue is partitioned between chloroform and water and extracted with chloroform. The combined organic phases are dried over sodium sulfate and concentrated in vacuo. 58.8 g (75.9% of theory) of the title compound are obtained.

来源