反应 #84022

反应方程式

sodium hydride

N-(3-chloro-1-(pyridin-3-yl)-1H-pyrazol-4-yl)-3-((3,3,3-trifluoropropyl)thio)propanamide

ethyl bromide

potassium iodide

→

N-(3-chloro-1-(pyridin-3-yl)-1H-pyrazol-4-yl)-N-ethyl-3-((3,3,3-trifluoropropyl)thio)propanamide

溶剂

sulfolane

sulfolane

反应条件

后处理

1. 1
   workup.ADDITIONwas slowly added dropwise over 5 minutes
2. 2
   其他after 3 minutes
3. 3
   workup.ADDITIONwere added sequentially
4. 4
   workup.STIRRINGto stir at room temperature
5. 5
   其他The reaction was quenched after 6 hours
6. 6
   workup.ADDITIONby being poured drop-wise
7. 7
   温度into cooled ammonium formate/acetonitrile solution (30 mL)
8. 8
   workup.STIRRINGThe resulting orange colored solution was stirred
9. 9
   workup.ADDITIONtetrahydrofuran (40 mL) was added

实验过程

To 3-neck round bottomed flask (50 mL) was added sodium hydride (60% in oil, 0.130 g, 3.28 mmol) and sulfolane (16 mL). The gray suspension was stirred for 5 minutes then N-(3-chloro-1-(pyridin-3-yl)-1H-pyrazol-4-yl)-3-((3,3,3-trifluoropropyl)thio)propanamide (1.20 g, 3.16 mmol) dissolved in sulfolane (25 mL) was slowly added dropwise over 5 minutes. The mixture became a light gray suspension after 3 minutes and was allowed to stir for 5 minutes after which time ethyl bromide (0.800 mL, 10.7 mmol) and potassium iodide (0.120 g, 0.720 mmol) were added sequentially. The cloudy suspension was then allowed to stir at room temperature. The reaction was quenched after 6 hours by being poured drop-wise into cooled ammonium formate/acetonitrile solution (30 mL). The resulting orange colored solution was stirred and tetrahydrofuran (40 mL) was added. The mixture was assayed, using octanophenone as a standard, and found to contain (1.09 g, 85%) of the desired product with a selectivity versus the retro-Michael-like decomposition product of 97:3.

来源