反应 #83974

反应方程式

4-(1H-indazol-3-yl)piperazine

N-(2-bromoethyl)phthalimide

sodium bicarbonate

→

N-[2-[4-(1H-indazol-3-yl)-1-piperazinyl]ethyl]phthalimide

溶剂

acetonitrile

反应条件

后处理

1. 1
   温度was warmed
2. 2
   温度to reflux for 24 hours
3. 3
   过滤the reaction mixture was filtered through a pad of celite
4. 4
   洗涤the solids were washed with DCM
5. 5
   浓缩The combined filtrates were concentrated

实验过程

A suspension of 4-(1H-indazol-3-yl)piperazine (1.6 g, 7.9 mmol), N-(2-bromoethyl)phthalimide (2.1 g, 7.9 mmol), and sodium bicarbonate (0.7 g, 8.3 mmol) in acetonitrile (160 ml) was warmed to reflux for 24 hours. Upon cooling to room temperature, the reaction mixture was filtered through a pad of celite and the solids were washed with DCM. The combined filtrates were concentrated to give the N-[2-[4-(1H-indazol-3-yl)-1-piperazinyl]ethyl]phthalimide which was used without further purification.

来源