反应 #83589

反应方程式

5-[3-hydroxy-2-(2-methoxycarbonylethyl)-6-pyridyl]-4-pentynoic acid methyl ester

→

5-[3-hydroxy-2-(2-methoxycarbonylethyl)-6-pyridyl]-pentanoic acid methyl ester

收率 65.6%

溶剂

methanol

反应条件

后处理

1. 1
   其他The crude product is chromatographed on silica gel with hexane/0-50% ethyl acetate

实验过程

Under the conditions of example 14 A, a solution of 1 g of 5-[3-hydroxy-2-(2-methoxycarbonylethyl)-6-pyridyl]-4-pentynoic acid methyl ester in 10 ml of methanol is hydrogenated in the presence of 100 mg of 10% palladium catalyst on activated carbon and worked up. The crude product is chromatographed on silica gel with hexane/0-50% ethyl acetate. 665 mg of 5-[3-hydroxy-2-(2-methoxycarbonylethyl)-6-pyridyl]-pentanoic acid methyl ester of melting point 92°-95° C. is obtained.

来源