反应 #833565

反应方程式

sodium chloride

1-(but-2-ynyl)-2-chloro-6-(quinolin-2-ylmethyl)-5,6-dihydro-1H-imidazo[4,5-d]-pyridazine-4,7-dione

potassium carbonate

bromoacetonitrile

→

1-(but-2-ynyl)-2-chloro-5-cyanomethyl-6-(quinolin-2-ylmethyl)-5,6-dihydro-1H-imidazo[4,5-d]pyridazine-4,7-dione

溶剂

dimethylformamide

反应条件

后处理

1. 1
   萃取is extracted three times with ethyl acetate
2. 2
   干燥the combined organic phases are dried over sodium sulphate
3. 3
   其他the solvent is removed
4. 4
   其他The residue is purified over silica gel (cyclohexane/ethyl acetate 1:1)

实验过程

0.20 g 1-(but-2-ynyl)-2-chloro-6-(quinolin-2-ylmethyl)-5,6-dihydro-1H-imidazo[4,5-d]-pyridazine-4,7-dione and 0.25 g potassium carbonate are placed in 4 ml of dimethylformamide. Then 53 μl of bromoacetonitrile are added and the mixture is stirred for 2 h at 40° C. After the addition of aqueous saturated sodium chloride solution the mixture is extracted three times with ethyl acetate, the combined organic phases are dried over sodium sulphate, and then the solvent is removed. The residue is purified over silica gel (cyclohexane/ethyl acetate 1:1).

来源