反应 #833564

反应方程式

methyl 2-chloro-5-[N′-tert-butoxycarbonyl-N-(quinolin-2-ylmethyl)-hydrazinocarbonyl]-1-(but-2-ynyl)-1H-imidazol-4-carboxylate

hydrochloric acid

→

1-(but-2-ynyl)-2-chloro-6-(quinolin-2-ylmethyl)-5,6-dihydro-1H-imidazo[4,5-d]-pyridazine-4,7-dione

溶剂

ethyl acetate

dioxane

反应条件

后处理

1. 1
   温度Then the solution is cooled to ambient temperature
2. 2
   其他the precipitate formed
3. 3
   其他is separated off
4. 4
   洗涤washed with ethyl acetate and diethyl ether
5. 5
   其他dried in the drying cupboard at 50° C.

实验过程

2.80 g methyl 2-chloro-5-[N′-tert-butoxycarbonyl-N-(quinolin-2-ylmethyl)-hydrazinocarbonyl]-1-(but-2-ynyl)-1H-imidazol-4-carboxylate are dissolved in 50 ml of ethyl acetate. Then 1.5 ml of 4 M hydrochloric acid in dioxane are added, and the solution is stirred for 2 h at 50° C. Then the solution is cooled to ambient temperature, the precipitate formed is separated off, washed with ethyl acetate and diethyl ether and dried in the drying cupboard at 50° C.

来源