反应 #833557

反应方程式

naphthalene-2-acetic acid

3-(N-methyl-sulfamoyl)-naphthalene-2-acetic acid

p-toluene-sulfonic acid

→

3,4-dihydro-2-methyl-3-oxo-2H-naphtho[2,3-e]-1,2-thiazine 1,1-dioxide

收率 61.1%

溶剂

xylene

反应条件

后处理

1. 1
   温度The reaction mixture was cooled
2. 2
   过滤filtered
3. 3
   洗涤washed with water
4. 4
   浓缩concentrated
5. 5
   其他Recrystallization from ethanol

实验过程

This naphthalene-2-acetic acid (2.6 g, 9.4 mmol) was 12 hrs refluxed in 100 mL xylene with the addition of 0.2 g p-toluene-sulfonic acid. The reaction mixture was cooled, filtered, washed with water and concentrated. Recrystallization from ethanol gave 1.5 g (61%) 3,4-dihydro-2-methyl-3-oxo-2H-naphtho[2,3-e]-1,2-thiazine 1,1-dioxide (melting point: 126-127° C.).

来源