反应 #833550

反应方程式

4.5-dimethoxy-2-nitrobenzyl 2-bromoacetate

NaI

→

4.5-dimethoxy-2-nitrobenzyl 2-iodoacetate

溶剂

acetone

反应条件

后处理

1. 1
   过滤mixture was filtered
2. 2
   其他evaporated
3. 3
   其他purified by chromatography (Si-gel, CH2Cl2)

实验过程

A 4.5-dimethoxy-2-nitrobenzyl 2-bromoacetate (100 mg, 0.3 mmol) was dissolved in acetone (2 ml) and NaI (50 mg, 0.33 mmol) was added. After stirring for two hours at room temperature, mixture was filtered, evaporated and purified by chromatography (Si-gel, CH2Cl2) to yield 4.5-dimethoxy-2-nitrobenzyl 2-iodoacetate (compound E (see FIG. 12c): P6—C1[X═I]) (97 mg, 85%).

来源