反应 #833549

反应方程式

Bromoacetylbromide

6-nitroveratrylalcohol

Et3N

CH2Cl2

→

4.5-dimethoxy-2-nitrobenzyl 2-bromoacetate

收率 55.1%

溶剂

CHCl3

反应条件

后处理

1. 1
   洗涤the mixture was washed with HCl (1 M, 2×10 ml), NaHCO3 (sat., 10 ml) and water (10 ml)
2. 2
   干燥Organic phase was dried over Na2SO4
3. 3
   其他evaporated
4. 4
   其他purified by chromatography (Si-gel, CH2Cl2)

实验过程

Bromoacetylbromide (0.19 ml, 2.2 mmol) was slowly added to the solution of 6-nitroveratrylalcohol (0.43 g, 2 mmol), Et3N (0.56 ml, 4 mmol) and DMAP (24 mg, 0.2 mmol) in CHCl3 (5 ml). After stirring at room temperature for five hours, CH2Cl2 (20 ml) was added and the mixture was washed with HCl (1 M, 2×10 ml), NaHCO3 (sat., 10 ml) and water (10 ml). Organic phase was dried over Na2SO4, evaporated and purified by chromatography (Si-gel, CH2Cl2) to yield 4.5-dimethoxy-2-nitrobenzyl 2-bromoacetate (368 mg, 55%).

来源